Occupational exposure to whole-body vibration and Parkinson's disease: results from a population-based case-control study.
Identifieur interne : 001166 ( Main/Exploration ); précédent : 001165; suivant : 001167Occupational exposure to whole-body vibration and Parkinson's disease: results from a population-based case-control study.
Auteurs : M Anne Harris [Canada] ; Stephen A. Marion ; John J. Spinelli ; Joseph K C. Tsui ; Kay TeschkeSource :
- American journal of epidemiology [ 1476-6256 ] ; 2012.
English descriptors
- KwdEn :
- Adult, Aged, British Columbia, Case-Control Studies, Female, Health Surveys, Humans, Logistic Models, Male, Middle Aged, Occupational Diseases (etiology), Occupational Exposure (adverse effects), Occupational Exposure (analysis), Occupational Exposure (statistics & numerical data), Odds Ratio, Parkinson Disease (etiology), Risk Factors, Self Report, Surveys and Questionnaires, Vibration (adverse effects).
- MESH :
- geographic : British Columbia.
- adverse effects : Occupational Exposure, Vibration.
- analysis : Occupational Exposure.
- etiology : Occupational Diseases, Parkinson Disease.
- statistics & numerical data : Occupational Exposure.
- Adult, Aged, Case-Control Studies, Female, Health Surveys, Humans, Logistic Models, Male, Middle Aged, Odds Ratio, Risk Factors, Self Report, Surveys and Questionnaires.
Abstract
Mechanical stress producing head injury is associated with Parkinson's disease, suggesting that relations with other physical hazards such as whole-body vibration (WBV) should be tested. In this study, the authors evaluated the relation between occupational exposure to WBV and Parkinson's disease. A population-based case-control study with 403 cases and 405 controls was conducted in British Columbia, Canada, between 2001 and 2008. From detailed occupational histories and published measurements, metrics of occupational WBV exposure were constructed and tested for associations with Parkinson's disease using logistic regression and adjusting for age and sex first, and then also for smoking and history of head injury. While ever being occupationally exposed to WBV was inversely associated with Parkinson's disease (odds ratio = 0.67, 95% confidence interval: 0.48, 0.94), higher intensities had consistently elevated odds ratios, with a statistically significant effect being noted for intermediate intensities when exposures were restricted to the 10 years or more prior to diagnosis. Possible mechanisms of an inverse relation between low levels of WBV exposure and Parkinson's disease could include direct protective effects or correlation with other protective effects such as exercise. Higher intensities of WBV could result in micro-injury, leading to vascular or inflammatory pathology in susceptible neurons.
DOI: 10.1093/aje/kws017
PubMed: 22798480
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Occupational exposure to whole-body vibration and Parkinson's disease: results from a population-based case-control study.</title><author><name sortKey="Harris, M Anne" sort="Harris, M Anne" uniqKey="Harris M" first="M Anne" last="Harris">M Anne Harris</name><affiliation wicri:level="1"><nlm:affiliation>School of Population and Public Health, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada. m.anne.harris@alumni.ubc.ca</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>School of Population and Public Health, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia</wicri:regionArea><wicri:noRegion>British Columbia</wicri:noRegion></affiliation></author><author><name sortKey="Marion, Stephen A" sort="Marion, Stephen A" uniqKey="Marion S" first="Stephen A" last="Marion">Stephen A. Marion</name></author><author><name sortKey="Spinelli, John J" sort="Spinelli, John J" uniqKey="Spinelli J" first="John J" last="Spinelli">John J. Spinelli</name></author><author><name sortKey="Tsui, Joseph K C" sort="Tsui, Joseph K C" uniqKey="Tsui J" first="Joseph K C" last="Tsui">Joseph K C. Tsui</name></author><author><name sortKey="Teschke, Kay" sort="Teschke, Kay" uniqKey="Teschke K" first="Kay" last="Teschke">Kay Teschke</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="RBID">pubmed:22798480</idno><idno type="pmid">22798480</idno><idno type="doi">10.1093/aje/kws017</idno><idno type="wicri:Area/PubMed/Corpus">000A36</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000A36</idno><idno type="wicri:Area/PubMed/Curation">000A36</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000A36</idno><idno type="wicri:Area/PubMed/Checkpoint">000A36</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000A36</idno><idno type="wicri:Area/Ncbi/Merge">001200</idno><idno type="wicri:Area/Ncbi/Curation">001200</idno><idno type="wicri:Area/Ncbi/Checkpoint">001200</idno><idno type="wicri:Area/Main/Merge">001188</idno><idno type="wicri:Area/Main/Curation">001166</idno><idno type="wicri:Area/Main/Exploration">001166</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Occupational exposure to whole-body vibration and Parkinson's disease: results from a population-based case-control study.</title><author><name sortKey="Harris, M Anne" sort="Harris, M Anne" uniqKey="Harris M" first="M Anne" last="Harris">M Anne Harris</name><affiliation wicri:level="1"><nlm:affiliation>School of Population and Public Health, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada. m.anne.harris@alumni.ubc.ca</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>School of Population and Public Health, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia</wicri:regionArea><wicri:noRegion>British Columbia</wicri:noRegion></affiliation></author><author><name sortKey="Marion, Stephen A" sort="Marion, Stephen A" uniqKey="Marion S" first="Stephen A" last="Marion">Stephen A. Marion</name></author><author><name sortKey="Spinelli, John J" sort="Spinelli, John J" uniqKey="Spinelli J" first="John J" last="Spinelli">John J. Spinelli</name></author><author><name sortKey="Tsui, Joseph K C" sort="Tsui, Joseph K C" uniqKey="Tsui J" first="Joseph K C" last="Tsui">Joseph K C. Tsui</name></author><author><name sortKey="Teschke, Kay" sort="Teschke, Kay" uniqKey="Teschke K" first="Kay" last="Teschke">Kay Teschke</name></author></analytic><series><title level="j">American journal of epidemiology</title><idno type="eISSN">1476-6256</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>British Columbia</term><term>Case-Control Studies</term><term>Female</term><term>Health Surveys</term><term>Humans</term><term>Logistic Models</term><term>Male</term><term>Middle Aged</term><term>Occupational Diseases (etiology)</term><term>Occupational Exposure (adverse effects)</term><term>Occupational Exposure (analysis)</term><term>Occupational Exposure (statistics & numerical data)</term><term>Odds Ratio</term><term>Parkinson Disease (etiology)</term><term>Risk Factors</term><term>Self Report</term><term>Surveys and Questionnaires</term><term>Vibration (adverse effects)</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>British Columbia</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Occupational Exposure</term><term>Vibration</term></keywords><keywords scheme="MESH" qualifier="analysis" xml:lang="en"><term>Occupational Exposure</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Occupational Diseases</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Occupational Exposure</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Case-Control Studies</term><term>Female</term><term>Health Surveys</term><term>Humans</term><term>Logistic Models</term><term>Male</term><term>Middle Aged</term><term>Odds Ratio</term><term>Risk Factors</term><term>Self Report</term><term>Surveys and Questionnaires</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Mechanical stress producing head injury is associated with Parkinson's disease, suggesting that relations with other physical hazards such as whole-body vibration (WBV) should be tested. In this study, the authors evaluated the relation between occupational exposure to WBV and Parkinson's disease. A population-based case-control study with 403 cases and 405 controls was conducted in British Columbia, Canada, between 2001 and 2008. From detailed occupational histories and published measurements, metrics of occupational WBV exposure were constructed and tested for associations with Parkinson's disease using logistic regression and adjusting for age and sex first, and then also for smoking and history of head injury. While ever being occupationally exposed to WBV was inversely associated with Parkinson's disease (odds ratio = 0.67, 95% confidence interval: 0.48, 0.94), higher intensities had consistently elevated odds ratios, with a statistically significant effect being noted for intermediate intensities when exposures were restricted to the 10 years or more prior to diagnosis. Possible mechanisms of an inverse relation between low levels of WBV exposure and Parkinson's disease could include direct protective effects or correlation with other protective effects such as exercise. Higher intensities of WBV could result in micro-injury, leading to vascular or inflammatory pathology in susceptible neurons.</div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><noCountry><name sortKey="Marion, Stephen A" sort="Marion, Stephen A" uniqKey="Marion S" first="Stephen A" last="Marion">Stephen A. Marion</name><name sortKey="Spinelli, John J" sort="Spinelli, John J" uniqKey="Spinelli J" first="John J" last="Spinelli">John J. Spinelli</name><name sortKey="Teschke, Kay" sort="Teschke, Kay" uniqKey="Teschke K" first="Kay" last="Teschke">Kay Teschke</name><name sortKey="Tsui, Joseph K C" sort="Tsui, Joseph K C" uniqKey="Tsui J" first="Joseph K C" last="Tsui">Joseph K C. Tsui</name></noCountry><country name="Canada"><noRegion><name sortKey="Harris, M Anne" sort="Harris, M Anne" uniqKey="Harris M" first="M Anne" last="Harris">M Anne Harris</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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